The guest lecture by Prof B Fischer of Nagoya University will be held on Thursday 28 June 2018 at the MM Room, Starting at 10.00 am. Registration is required to join this open lecture. Please make sure you check the time and you can definitely join the lecture before registering to this lecture. The registration closes on 26 June 2018 at 16.00.
Link for registration https://goo.gl/forms/Y7w35JwypOgmcyf42
“Bioinorganic chemistry of Molybdenum and Pterin containing enzymes”
Berthold Fischer, Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho Chikusa-ku, Nagoya 464-8602, Japan
Molybdenum (Mo) and tungsten (W) centers in pterin dependent enzymes catalyze important redox reactions in the global carbon, nitrogen, and sulfur cycles. In these enzymes both metals bind to a unique pterin (MPT) that is synthesized by a strictly conserved multistep biosynthetic pathway, which ends with the insertion and biological activation of the respective element in the active catalytic cofactor called Moco. It is commonly believed that also tungsten-containing pterin cofactors, mostly found in Archaea, are synthesized in a similar way as Moco with a specific mechanism for tungsten incorporation.
We will give an overview on efforts to elucidate the possible reactions of hydrogenated pterin model compounds with molybdenum centers and their potential relevance to the reactions in enzyme centers. Furthermore a different approach using biosynthetic intermediates and their use in medical treatments will be described.